Overview
Description
Organic reactions not generally covered in introductory courses in organic chemistry. Emphasis on both synthetic utility and reaction mechanisms.
Units
Lecture3
Catalog Details
Offering
Offered: Every Fall
Terms
fall
Attributes
Standard
Learning Outcomes
- identify and compare steric, electronic, and stereoelectronic effects.
- analyze the stereochemistry of molecules and assign correct configurations.
- evaluate and explain carbocation stability and reactivity in classic and non-classical cationic systems.
- contrast thermodynamic and kinetic control in reactions, and explain and apply primary and secondary kinetic isotope effects, transition-state theory, Curtin-Hammett principle, Hammett plots, and the Hammond postulate.
- evaluate addition and elimination reactions and predict and explain reaction outcomes by drawing clear “arrow-pushing” mechanisms along with the regio-, stereo-, and chemoselectivity of these reactions.
- evaluate and explain substitution and thermal isomerization reactions by drawing clear arrow-pushing mechanisms and the regio-, stereo-, and chemoselectivity in these reactions.
- evaluate and explain pericyclic reactions (cycloadditions, electrocyclizations, and sigmatropic rearrangements) and propose their mechanisms, using the concepts of aromaticity and Frontier Molecular Orbital (FMO) theory.